Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DPYD | Q12882 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933269 | 0.70 | DAO (0.40) | DAOALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL7903836 | 0.69 | UPP1 (0.48) | DAOMAPTKDM4EDPYDKMT2A | |
| SCHEMBL7906397 | 0.68 | UPP1 (0.47) | DAOMAPTKDM4EDPYDKMT2A | |
| SCHEMBL17603120 | 0.65 | AR (0.43) | DAOALDH1A1HTTMAPTLMNA | |
| SCHEMBL24566204 | 0.62 | KDM4E (0.45) | DAOALDH1A1HTTMAPTLMNA | |
| SCHEMBL27284697 | 0.59 | DPYD (0.37) | DPYDKMT2AMEN1 | |
| SCHEMBL9489932 | 0.57 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL24070359 | 0.57 | TRPV4 (0.59) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9971326 | 0.56 | GRIA1 (0.63) | ALDH1A1MAPTLMNATSHRTHPO | |
| SCHEMBL27977648 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104473-A2 | PYRAZOLOPYRIIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008104473-A2 | PYRAZOLOPYRIIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-04 | — | — | WO | disclosed |
| US-20080207684-A1 | Kinase inhibitors and methods for using the same | ROCHE PALO ALTO LLC | 2008-08-28 | — | — | US | disclosed |
| US-20080207684-A1 | Kinase inhibitors and methods for using the same | ROCHE PALO ALTO LLC | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207684-A1 | Kinase inhibitors and methods for using the same | MAP3K1, MAPK1, MAP3K20 | DAO 3682/4885ALDH1A1 2354/4885HTT 2716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.