SCHEMBL4742939

SCHEMBL4742939

CCCCc1c(N)cccc1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SKP2 Q13309 1/20 0.48
CYP3A4 P08684 2/20 0.46
TSHR P16473 2/20 0.46
PIK3CA P42336 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
CD44 P16070 1/20 0.41
PARP1 P09874 1/20 0.40
KCNH2 Q12809 2/20 0.39
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
GCGR P47871 1/20 0.39
TLR8 Q9NR97 3/20 0.39
NOS2 P35228 1/20 0.38
ALDH1A1 P00352 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5812363 0.93 KCNH2 (0.47) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL10492522 0.91 KCNH2 (0.50) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL3397890 0.91 KCNH2 (0.50) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL27755339 0.91 KCNH2 (0.50) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL4252594 0.89 SKP2 (0.48) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL140512 0.87 SKP2 (0.43) SKP2CYP3A4TSHRPIK3CACYP1A2
Hydrogen Sulfide SCHEMBL27537530 0.87 SKP2 (0.47) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL11465695 0.86 SKP2 (0.42) SKP2CYP3A4TSHRPIK3CACYP1A2
SCHEMBL1026540 0.86 HTT (0.46) SKP2TSHRCYP1A2CYP2C9CYP2C19
SCHEMBL3784038 0.86 ALDH1A1 (0.50) SKP2CYP3A4TSHRPIK3CACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102918073-B Polyurethane compositions with improved impact resistance and optical properties DOW GLOBAL TECHNOLOGIES LLC 2014-12-10 CN disclosed
CN-103554414-A Polyurethane-urea elastomers BAYER MATERIALSCIENCE LLC 2014-02-05 CN disclosed
CN-102414235-B Castable polyurea compositions for golf ball covers DOW GLOBAL TECHNOLOGIES INC 2013-09-04 CN disclosed
CN-102918073-A Polyurethane compositions with improved impact resistance and optical properties DOW GLOBAL TECHNOLOGIES LLC 2013-02-06 CN disclosed
CN-101516948-B Diamine chain extender compositions ALBEMARLE CORP 2012-08-15 CN disclosed
CN-101568566-B Formulations for reaction injection molding and for spray systems ALBEMARLE CORP 2012-07-11 CN disclosed
CN-101541847-B Spray-applied polyurethane urea compounds based on polyisocyanate prepolymers containing soft segments BAYER MATERIALSCIENCE LLC 2012-05-30 CN disclosed
CN-102414235-A Castable polyurea compositions for golf ball covers DOW GLOBAL TECHNOLOGIES INC 2012-04-11 CN disclosed
CN-101891629-A Diimine and secondary diamine ALBEMARLE CORP 2010-11-24 CN disclosed
CN-101568566-A Formulations for reaction injection molding and for spray systems ALBEMARLE CORP (US) 2009-10-28 CN disclosed
WO-2008112636-A1 CHAIN EXTENDERS ALBEMARLE CORPORATION (US) 2008-09-18 WO disclosed
CN-101160283-A Diimines and secondary diamines ALBEMARLE CORP (US) 2008-04-09 CN disclosed
CN-1247649-C One-step method polyurethane-urea elastomer with light stability BAYER CORP (US) 2006-03-29 CN disclosed
CN-1412214-A One-step method polyurethane-urea elastomer with light stability BAYER AG (US) 2003-04-23 CN disclosed
WO-2000077062-A1 CLEAR, RESILIENT POLYURETHANE ELASTOMERS UNIROYAL CHEMICAL COMPANY, INC. (US) 2000-12-21 WO disclosed
US-4868225-A STERICALLY HINDERED META-PHENYLENEDIAMINE CHAIN EXTENDER FOR POLYURETHANES THE DOW CHEMICAL COMPANY (US) 1989-09-19 US disclosed
US-4866208-A CURING AGENT FOR EPOXY RESINS; EXTENDERS FOR POLYUREA-URETHANE COPOLYMERS THE DOW CHEMICAL COMPANY (US) 1989-09-12 US disclosed
US-4792623-A CURING AGENT, EXTENDER THE DOW CHEMICAL COMPANY (US) 1988-12-20 US disclosed
EP-0082258-B1 SUBSTITUTED M-PHENYLENEDIAMINES THE DOW CHEMICAL COMPANY (US) 1986-02-19 EP disclosed
EP-0082258-A1 Substituted m-phenylenediamines THE DOW CHEMICAL COMPANY (US) 1983-06-29 EP disclosed