SCHEMBL3397890

SCHEMBL3397890

CCCCCCCCCCCCc1c(N)cccc1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.50
HTR2A P28223 1/20 0.45
PARP1 P09874 1/20 0.45
TLR8 Q9NR97 3/20 0.44
GCGR P47871 1/20 0.43
GPR84 Q9NQS5 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
TSHR P16473 2/20 0.42
CYP3A4 P08684 2/20 0.42
PIK3CA P42336 1/20 0.42
LIPG Q9Y5X9 1/20 0.41
SKP2 Q13309 1/20 0.41
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
HSD17B10 Q99714 2/20 0.41
POLB P06746 1/20 0.41
ESR1 P03372 2/20 0.41
ADRA2A P08913 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27755339 1.00 KCNH2 (0.50) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL10492522 1.00 KCNH2 (0.50) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL5812363 0.98 KCNH2 (0.47) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL4742939 0.91 SKP2 (0.48) KCNH2PARP1TLR8GCGRCYP1A2
SCHEMBL28289695 0.90 KCNH2 (0.46) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL21385098 0.90 KCNH2 (0.46) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL6825844 0.90 KCNH2 (0.46) KCNH2HTR2APARP1TLR8GCGR
SCHEMBL20356884 0.89 F7 (0.47) KCNH2KDM4EHSD17B10
SCHEMBL2293519 0.88 LIPG (0.49) KCNH2PARP1TLR8LIPGPTGS2
SCHEMBL9019468 0.88 LIPG (0.49) KCNH2PARP1TLR8LIPGPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109196079-B Synergistic lubricating oil compositions containing antioxidant mixtures 雪佛龙奥伦耐有限责任公司 2022-04-05 CN disclosed
EP-3484983-B1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE CO (US) 2020-05-27 EP disclosed
EP-3484983-A1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS Chevron Oronite Company LLC (US) 2019-05-22 EP disclosed
US-10077410-B2 Synergistic lubricating oil composition containing mixture of antioxidants CHEVRON ORONITE COMPANY LLC (US) 2018-09-18 US disclosed
US-20180016512-A1 Synergistic Lubricating Oil Composition Containing Mixture of Antioxidants CHEVRON ORONITE COMPANY LLC 2018-01-18 US disclosed
WO-2018013181-A1 SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING MIXTURE OF ANTIOXIDANTS CHEVRON ORONITE COMPANY LLC (US) 2018-01-18 WO disclosed
EP-2245123-B1 METHODS FOR PRODUCING ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS CHEMTURA CORP (US) 2017-07-19 EP disclosed
US-8987515-B2 Cross products and co-oligomers of phenylenediamines and aromatic amines as antioxidants for lubricants CHEMTURA CORPORATION (US) 2015-03-24 US disclosed
US-8563489-B2 Alkylated 1,3-benzenediamine compounds and methods for producing same CHEMTURA CORPORATION (US) 2013-10-22 US disclosed
US-20130150275-A1 Cross Products and Co-Oligomers of Phenylenediamines and Aromatic Amines as Antioxidants for Lubricants CHEMTURA CORPORATION (US) 2013-06-13 US disclosed
CN-101896584-A Cycloalkylphenylenediamines as deposit control agents for lubricants CHEMTURA CORP 2010-11-24 CN disclosed
CN-101896585-A Alkylated 1, 3-phenylenediamine compound and process for producing the same CHEMTURA CORP 2010-11-24 CN disclosed
EP-2245123-A2 ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME Chemtura Corporation (US) 2010-11-03 EP disclosed
WO-2009076091-A2 ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME CHEMTURA CORPORATION (US) 2009-06-18 WO disclosed
US-20090156441-A1 Cycloalkyl phenylenediamines as deposit control agents for lubricants GREAT LAKES CHEMICAL GLOBAL, INC. 2009-06-18 US disclosed
US-20090156449-A1 ALKYLATED 1,3-BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME LANXESS SOLUTIONS US INC. 2009-06-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156449-A1 ALKYLATED 1,3-BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME BBOX1, ABHD5, BRD1 KCNH2 2766/4885HTR2A 1470/4885PARP1 821/4885
US-20090156441-A1 Cycloalkyl phenylenediamines as deposit control agents for lubricants C5, C9, C1S KCNH2 3766/4885HTR2A 1383/4885PARP1 854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.