Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14068800 | 0.92 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068797 | 0.90 | ALDH1A1 (0.74) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068550 | 0.89 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068539 | 0.88 | ALDH1A1 (0.78) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL4745033 | 0.86 | ALDH1A1 (0.61) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068549 | 0.85 | THRB (0.76) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068786 | 0.85 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068380 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068803 | 0.80 | ALDH1A1 (0.68) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068384 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | claimed |
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |