Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28180977 | 1.00 | HRH3 (0.60) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL17971426 | 1.00 | HRH3 (0.60) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL28180989 | 1.00 | HRH3 (0.60) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL28180976 | 1.00 | HRH3 (0.60) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL28180194 | 1.00 | HRH3 (0.60) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL4937120 | 0.98 | HRH3 (0.57) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL10532793 | 0.95 | HRH3 (0.56) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL519168 | 0.93 | DRD2 (0.58) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL9175694 | 0.91 | PTGS2 (0.62) | HRH3DRD2DRD4DRD3KCNH2 | |
| SCHEMBL9175695 | 0.91 | PTGS2 (0.62) | HRH3DRD2DRD4DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107353209-B | There are the two phenoxy group flexible molecules and its preparation method and application of high-affinity with A β plaque block | 北京师范大学 | 2019-07-19 | — | — | CN | disclosed |
| CN-107353209-A | There are two phenoxy group flexible molecules of high-affinity and its preparation method and application with A β plaque block | 北京师范大学 | 2017-11-17 | — | — | CN | disclosed |
| WO-2008107320-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |
| EP-0680472-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014673-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA S.P.A. (IT) | 1995-06-01 | — | — | WO | disclosed |