Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013240 | 0.80 | HPGD (0.75) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL13958758 | 0.77 | USP2 (0.69) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL14067517 | 0.75 | POLB (0.69) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL13973078 | 0.75 | HPGD (0.61) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL13923633 | 0.75 | RAB9A (0.65) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL13543185 | 0.75 | HPGD (0.55) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL708029 | 0.75 | POLB (0.77) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL14067736 | 0.74 | SMN1; SMN2 (0.53) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL4651767 | 0.74 | RAB9A (0.71) | HPGDHTTPOLBMEN1KMT2A | |
| SCHEMBL7976728 | 0.73 | POLB (0.62) | HPGDHTTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008106633-A1 | METHODS OF USING BENZODIOXINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008106633-A1 | METHODS OF USING BENZODIOXINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-04 | — | — | WO | disclosed |