Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 7/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013240 | 0.82 | HPGD (0.75) | POLBHPGDMEN1KMT2AGAA | |
| SCHEMBL19550524 | 0.80 | POLB (0.73) | POLBHPGDMEN1KMT2AHTT | |
| SCHEMBL19550956 | 0.80 | POLB (0.73) | POLBHPGDMEN1KMT2AHTT | |
| SCHEMBL19550522 | 0.80 | POLB (0.73) | POLBHPGDMEN1KMT2AHTT | |
| SCHEMBL7339035 | 0.80 | HPGD (0.71) | POLBHPGDMEN1KMT2AGAA | |
| SCHEMBL4651767 | 0.79 | RAB9A (0.71) | POLBHPGDMEN1KMT2AGAA | |
| SCHEMBL8846668 | 0.78 | GAA (0.70) | POLBHPGDMEN1KMT2AGAA | |
| SCHEMBL14067517 | 0.78 | POLB (0.69) | POLBHPGDMEN1KMT2AGAA | |
| SCHEMBL13923633 | 0.77 | RAB9A (0.65) | POLBHPGDMEN1KMT2AHTT | |
| SCHEMBL2977327 | 0.76 | NISCH (0.71) | POLBHPGDMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476307-B2 | pharmaceutical composition comprising idazoxan or derivatives and their therapeutically acceptable salts, racemates, optically active isomers and polymorphs. | PIERRE FABRE MEDICAMENT (FR) | 2013-07-02 | — | — | US | disclosed |
| US-8124640-B2 | non-film-coated tablets comprising a mixture of 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride, microcrystalline cellulose, lubricants, colloidal silica and lactose, having stability | PIERRE FABRE MEDICAMENT (FR) | 2012-02-28 | — | — | US | disclosed |
| US-7595335-B2 | Containing microcrystalline cellulose, lubricant, colloidal silica and lactose; use in treating depression, Parkinson's disease and severe psychotic disorders, such as schizophrenia and schizoaffective disorders. | PIERRE FABRE MEDICAMENT (FR) | 2009-09-29 | — | — | US | disclosed |
| US-20080262067-A1 | PHARMACEUTICAL COMPOSITION BASED ON IDAZOXAN, SALTS, HYDRATES OR POLYMORPHS THEREOF | PIERRE FABRE MEDICAMENT | 2008-10-23 | — | — | US | disclosed |
| US-20080113022-A1 | PHARMACEUTICAL COMPOSITION BASED ON IDAZOXAN, SALTS, HYDRATES OR POLYMORPHS THEREOF | BOUGARET JOEL | 2008-05-15 | — | — | US | disclosed |
| US-7338970-B2 | Pharmaceutical composition based on a polymorphic form I of idazoxan | PIERRE FABRE MEDICAMENT (FR) | 2008-03-04 | — | — | US | disclosed |
| US-20050176798-A1 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof | PIERRE FABRE MEDICAMENT (FR) | 2005-08-11 | — | — | US | disclosed |
| US-20050090537-A1 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof | PIERRE FABRE MEDICAMENT (FR) | 2005-04-28 | — | — | US | disclosed |
| US-4818764-A | SELECTIVE PRESYNAPTIC ADRENERGIC BLOCKING AGENT OF 2-/2-/1,4-BENZODIOXANYL//-2-IMIDAZOLINE | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1989-04-04 | — | — | US | disclosed |
| EP-0033655-B1 | IMIDAZOLINE DERIVATIVE, ITS SALTS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1984-04-25 | — | — | EP | disclosed |
| EP-0033655-A2 | Imidazoline derivative, its salts, process for preparation and pharmaceutical compositions thereof | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1981-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176798-A1 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof | CYP3A43, ABCG2, CYP2C9 | POLB 2453/4885HPGD 973/4885MEN1 2587/4885 |
| US-20080113022-A1 | PHARMACEUTICAL COMPOSITION BASED ON IDAZOXAN, SALTS, HYDRATES OR POLYMORPHS THEREOF | LPXN, ALB, SI | POLB 3491/4885HPGD 3332/4885MEN1 2615/4885 |
| US-20080262067-A1 | PHARMACEUTICAL COMPOSITION BASED ON IDAZOXAN, SALTS, HYDRATES OR POLYMORPHS THEREOF | CYP3A43, ABCG2, CYP2C9 | POLB 2453/4885HPGD 973/4885MEN1 2587/4885 |
| US-20050090537-A1 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof | LPXN, ALB, SI | POLB 3491/4885HPGD 3332/4885MEN1 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.