Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CHUK | O15111 | 8/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 6/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745741 | 0.87 | CHUK (0.58) | DYRK1ACHUKPRMT5WDR77IKBKB | |
| SCHEMBL4743685 | 0.85 | PRMT5 (0.50) | DYRK1APRMT5WDR77AAK1GSK3B | |
| SCHEMBL4744137 | 0.84 | PRMT5 (0.54) | DYRK1ACHUKPRMT5WDR77AAK1 | |
| SCHEMBL31430967 | 0.81 | PRMT5 (0.44) | DYRK1ACHUKPRMT5WDR77IKBKB | |
| SCHEMBL4745695 | 0.81 | DYRK1B (0.64) | DYRK1ACHUKPRMT5WDR77IKBKB | |
| SCHEMBL21069142 | 0.80 | PRMT5 (0.54) | DYRK1APRMT5WDR77AAK1GSK3B | |
| SCHEMBL4200987 | 0.78 | MAPK8 (0.60) | DYRK1APRMT5WDR77AAK1GSK3B | |
| SCHEMBL4746507 | 0.78 | DYRK1A (0.56) | DYRK1APRMT5WDR77AAK1LRRK2 | |
| SCHEMBL28315234 | 0.78 | KIT (0.53) | DYRK1APRMT5WDR77CA12CA1 | |
| SCHEMBL4745720 | 0.77 | PRMT5 (0.52) | DYRK1ACHUKPRMT5WDR77IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |