Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200987 | 0.83 | MAPK8 (0.60) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4743347 | 0.82 | PRMT5 (0.56) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4744094 | 0.81 | PRMT5 (0.45) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4746507 | 0.81 | DYRK1A (0.56) | PRMT5WDR77LRRK2AAK1CLK1 | |
| SCHEMBL4747825 | 0.80 | PRMT5 (0.49) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4743365 | 0.80 | DYRK1A (0.58) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4785608 | 0.79 | PRMT5 (0.48) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4746489 | 0.78 | MAPK8 (0.51) | PRMT5WDR77LRRK2KITAAK1 | |
| SCHEMBL4743685 | 0.78 | PRMT5 (0.50) | PRMT5WDR77LRRK2AAK1DYRK1A | |
| SCHEMBL4745695 | 0.78 | DYRK1B (0.64) | PRMT5WDR77CYP2C9CYP2C19CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478684-B1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | FERMION OY (FI) | 2020-04-15 | — | — | EP | disclosed |
| US-10407427-B2 | Processes for the preparation of Vemurafenib | FERMION OY (FI) | 2019-09-10 | — | — | US | disclosed |
| US-20190194197-A1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | FERMION OY (FI) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407427-B2 | Processes for the preparation of Vemurafenib | BRAF, NRAS, PDCD1 | PRMT5 887/4885WDR77 4066/4885LRRK2 415/4885 |
| US-20190194197-A1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | BRAF, RAF1, NRAS | PRMT5 1056/4885WDR77 4133/4885LRRK2 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.