Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744137 | 0.88 | PRMT5 (0.54) | PRMT5WDR77NTRK1PIK3CAAAK1 | |
| SCHEMBL4745741 | 0.83 | CHUK (0.58) | PRMT5WDR77NTRK1PIK3CAAAK1 | |
| SCHEMBL4743365 | 0.77 | DYRK1A (0.58) | PRMT5WDR77AAK1KITTNIK | |
| SCHEMBL4746500 | 0.77 | TNIK (0.58) | PRMT5WDR77NTRK1PIK3CAAAK1 | |
| SCHEMBL4743685 | 0.73 | PRMT5 (0.50) | PRMT5WDR77PIK3CAAAK1SGK1 | |
| SCHEMBL4746507 | 0.73 | DYRK1A (0.56) | PRMT5WDR77AAK1NEK1LRRK2 | |
| SCHEMBL4747765 | 0.71 | IMPDH2 (0.62) | PRMT5WDR77AAK1KITSGK1 | |
| SCHEMBL4745695 | 0.70 | DYRK1B (0.64) | PRMT5WDR77NTRK1TNIKDYRK1A | |
| SCHEMBL4747692 | 0.70 | TNIK (0.63) | PRMT5WDR77NTRK1AAK1NEK1 | |
| SCHEMBL21069142 | 0.70 | PRMT5 (0.54) | PRMT5WDR77AAK1KITTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |