Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153051 | 0.97 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1KDM4EHPGDRXFP1 | |
| SCHEMBL4689951 | 0.87 | RAB9A (0.53) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL3149234 | 0.84 | NPC1 (0.49) | SMN1; SMN2ALDH1A1HPGDKMT2APPARG | |
| SCHEMBL4688458 | 0.84 | MMP9 (0.40) | SMN1; SMN2ALDH1A1KDM4EHPGDRXFP1 | |
| SCHEMBL3139387 | 0.83 | KMT2A (0.47) | SMN1; SMN2ALDH1A1KMT2APPARGPPARD | |
| SCHEMBL3139824 | 0.82 | RAB9A (0.57) | SMN1; SMN2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL3149061 | 0.81 | RAB9A (0.54) | SMN1; SMN2ALDH1A1HPGDKMT2APPARG | |
| SCHEMBL3144225 | 0.80 | SSTR4 (0.46) | ALDH1A1KMT2APPARGPPARDPPARA | |
| SCHEMBL3153073 | 0.80 | MEN1 (0.50) | ALDH1A1KDM4EKMT2APPARGPPARD | |
| SCHEMBL13313677 | 0.79 | PPARG (0.43) | ALDH1A1KMT2APPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768954-A4 | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1768954-A2 | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006002361-A2 | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |