Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 10/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732670 | 0.85 | CA1 (0.45) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL153319 | 0.83 | JAK3 (0.44) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL384451 | 0.83 | JAK3 (0.44) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL153320 | 0.83 | JAK3 (0.44) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL16654342 | 0.82 | CA1 (0.48) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL4476340 | 0.81 | CTSK (0.49) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL4476337 | 0.81 | CTSK (0.49) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL1655475 | 0.81 | CTSK (0.49) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL8241826 | 0.79 | JAK3 (0.46) | JAK3BTKCA1CA2CA7 | |
| SCHEMBL8219736 | 0.79 | JAK3 (0.43) | JAK3BTKCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014184235-A1 | BENZAMIDE TRPA1 ANTAGONISTS | Acturum Life Science AB (SE) | 2014-11-20 | — | — | WO | disclosed |
| EP-1883633-A2 | HETEROCYCLIC ANTI-VIRAL COMPOUNDS COMPRISING METABOLIZABLE MOIETIES AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2007027230-A2 | HETEROCYCLIC ANTI-VIRAL COMPOUNDS COMPRISING METABOLIZABLE MOIETIES AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-08 | — | — | WO | disclosed |