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Dexamethasone

Dexamethasone

SCHEMBL4743981

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nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Dexamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.65
▸ HSD17B10 Q99714 9/20 0.65
▸ HIF1A Q16665 8/20 0.65
▸ CYP3A4 P08684 7/20 0.65
▸ PGR P06401 5/20 0.65
▸ AR P10275 3/20 0.65
▸ NFKB1 P19838 3/20 0.65
▸ TSHR P16473 2/20 0.65
▸ NR3C2 P08235 2/20 0.65
▸ MEN1 O00255 2/20 0.65
▸ KMT2A Q03164 2/20 0.65
▸ PMP22 Q01453 2/20 0.65
▸ CYP2D6 P10635 1/20 0.65
▸ APEX1 P27695 1/20 0.65
▸ NPSR1 Q6W5P4 1/20 0.65
▸ IKBKB O14920 1/20 0.65
▸ CHUK O15111 1/20 0.65
▸ ADRB2 P07550 1/20 0.65
▸ PLA2G2A P14555 1/20 0.65
▸ NFKB2 Q00653 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dexamethasone SCHEMBL1408949 0.95 NR3C1 (0.72) HSD17B10HIF1ACYP3A4NR3C1PGR
Betamethasone SCHEMBL13724083 0.95 NR3C1 (0.72) HSD17B10HIF1ACYP3A4NR3C1PGR
Dexamethasone SCHEMBL3309785 0.94 NR3C1 (0.73) HSD17B10HIF1ACYP3A4NR3C1PGR
Betamethasone SCHEMBL7070539 0.94 NR3C1 (0.73) HSD17B10HIF1ACYP3A4NR3C1PGR
Clobetasol SCHEMBL2857967 0.91 NR3C1 (0.67) HSD17B10HIF1ACYP3A4NR3C1PGR
Triamcinolone SCHEMBL3043158 0.90 HSD17B10 (0.71) HSD17B10HIF1ACYP3A4NR3C1PGR
Dexamethasone SCHEMBL20767432 0.90 CYP3A4 (0.66) HSD17B10HIF1ACYP3A4NR3C1PGR
Triamcinolone SCHEMBL5151654 0.89 HIF1A (0.72) HSD17B10HIF1ACYP3A4NR3C1PGR
Betamethasone Acetate SCHEMBL3882689 0.89 HIF1A (0.71) HSD17B10HIF1ACYP3A4NR3C1PGR
Betamethasone SCHEMBL20576476 0.87 CYP3A4 (0.69) HSD17B10HIF1ACYP3A4NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2776387-A1 TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION Emory University (US) 2014-09-17 — — EP disclosed
WO-2013070660-A1 TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION EMORY UNIVERSITY (US) 2013-05-16 — — WO disclosed
WO-2008112156-A1 CHEMOKINE RECEPTOR MODULATORS ALTIRIS THERAPEUTICS (US) 2008-09-18 — — WO disclosed
WO-2008109154-A1 CHEMOKINE RECEPTOR MODULATORS ALTIRIS THERAPEUTICS, INC. (US) 2008-09-12 — — WO disclosed
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