Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triamcinolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.72 |
| ▸ | PGR | P06401 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.72 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | AR | P10275 | 3/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.71 |
| ▸ | TNF | P01375 | 1/20 | 0.71 |
| ▸ | IL6 | P05231 | 1/20 | 0.71 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.71 |
| ▸ | GLUL | P15104 | 1/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL3309785 | 0.94 | NR3C1 (0.73) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Betamethasone SCHEMBL7070539 | 0.94 | NR3C1 (0.73) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Triamcinolone SCHEMBL21253255 | 0.92 | HIF1A (0.62) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Triamcinolone SCHEMBL3880195 | 0.91 | CYP3A4 (0.69) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Triamcinolone SCHEMBL22494815 | 0.91 | CYP3A4 (0.68) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Clobetasol SCHEMBL2857967 | 0.91 | NR3C1 (0.67) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Triamcinolone SCHEMBL593313 | 0.91 | HIF1A (0.68) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Dexamethasone SCHEMBL20767432 | 0.90 | CYP3A4 (0.66) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Dexamethasone SCHEMBL4743981 | 0.89 | HSD17B10 (0.65) | HIF1ACYP3A4HSD17B10NR3C1PGR | |
| Triamcinolone SCHEMBL3043158 | 0.88 | HSD17B10 (0.71) | HIF1ACYP3A4HSD17B10NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200306183-A1 | POLYMER COMPOSITE FOR CONTROLLED RELEASE OF AN AGENT | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2020-10-01 | — | — | US | disclosed |
| EP-3389721-A1 | POLYMER COMPOSITE FOR CONTROLLED RELEASE OF AN AGENT | Commonwealth Scientific and Industrial Research Organisation (AU) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017100858-A1 | POLYMER COMPOSITE FOR CONTROLLED RELEASE OF AN AGENT | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2017-06-22 | — | — | WO | disclosed |
| US-20070004692-A1 | Preparations and therapy of intrathecal inflammatory disease | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-01-04 | — | — | US | disclosed |