Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | ITK | Q08881 | 4/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069142 | 0.81 | PRMT5 (0.54) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL4743347 | 0.77 | PRMT5 (0.56) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL31049378 | 0.77 | LRRK2 (0.51) | PRMT5WDR77AAK1LRRK2MAP3K12 | |
| SCHEMBL4746489 | 0.74 | MAPK8 (0.51) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL4209183 | 0.73 | CYP11B1 (0.49) | PRMT5WDR77AAK1LRRK2AXL | |
| SCHEMBL8256245 | 0.71 | CDK8 (0.57) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL8258473 | 0.71 | CDK8 (0.57) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL4200987 | 0.71 | MAPK8 (0.60) | PRMT5WDR77KITAAK1LRRK2 | |
| SCHEMBL4746507 | 0.71 | DYRK1A (0.56) | PRMT5WDR77AAK1LRRK2CLK1 | |
| SCHEMBL9278508 | 0.70 | ALK (0.54) | PRMT5WDR77LRRK2MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |