Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069142 | 0.82 | PRMT5 (0.54) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL4200987 | 0.80 | MAPK8 (0.60) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL4746507 | 0.80 | DYRK1A (0.56) | PRMT5WDR77AAK1LRRK2CLK1 | |
| SCHEMBL4209183 | 0.78 | CYP11B1 (0.49) | PRMT5WDR77CYP11B2CYP11B1AAK1 | |
| SCHEMBL4744094 | 0.77 | PRMT5 (0.45) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL31049378 | 0.77 | LRRK2 (0.51) | PRMT5WDR77AAK1LRRK2 | |
| SCHEMBL4746489 | 0.77 | MAPK8 (0.51) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL8256245 | 0.77 | CDK8 (0.57) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL8258473 | 0.77 | CDK8 (0.57) | PRMT5WDR77AAK1LRRK2KIT | |
| SCHEMBL4743363 | 0.76 | MAP3K11 (0.58) | PRMT5WDR77AAK1LRRK2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |