SCHEMBL4744641

SCHEMBL4744641

Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1COc1cccc(CN2CCC[C@@H]2C(=O)O)c1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 10/20 0.56
PPARA Q07869 10/20 0.56
CYP2C9 P11712 2/20 0.56
KCNH2 Q12809 2/20 0.56
CD274 Q9NZQ7 1/20 0.52
KDR P35968 1/20 0.51
PTPN1 P18031 1/20 0.49
POLB P06746 1/20 0.49
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4746251 1.00 PPARG (0.56) PPARGPPARACYP2C9KCNH2CD274
SCHEMBL4748381 1.00 PPARG (0.56) PPARGPPARACYP2C9KCNH2CD274
SCHEMBL4744476 0.98 PPARG (0.55) PPARGPPARACYP2C9KCNH2CD274
SCHEMBL4744118 0.98 PPARG (0.55) PPARGPPARACYP2C9KCNH2CD274
SCHEMBL4787443 0.93 PPARG (0.57) PPARGPPARACYP2C9KCNH2
SCHEMBL4787454 0.93 PPARG (0.57) PPARGPPARACYP2C9KCNH2
SCHEMBL4748208 0.92 PPARG (0.53) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4743922 0.92 PPARG (0.53) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4743930 0.92 PPARG (0.53) PPARGPPARACYP2C9KCNH2KDR
SCHEMBL4746619 0.91 CD274 (0.60) PPARGPPARACYP2C9KCNH2CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO claimed
WO-2008117982-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME CRYSTAL GENOMICS, INC. (KR) 2008-10-02 WO disclosed