⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20758575 | 1.00 | — | — | |
| SCHEMBL10062020 | 1.00 | — | — | |
| SCHEMBL27379204 | 1.00 | — | — | |
| SCHEMBL10061284 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL30665810 | 0.97 | — | — | |
| SCHEMBL657268 | 0.87 | SLC6A1 (0.35) | — | |
| SCHEMBL20202125 | 0.87 | MBTD1 (0.36) | — | |
| SCHEMBL4124624 | 0.87 | MBTD1 (0.36) | — | |
| SCHEMBL29412823 | 0.87 | MBTD1 (0.36) | — | |
| SCHEMBL1545958 | 0.85 | EPAS1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611743-A1 | TRIAZINES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 | Merck Sharp & Dohme LLC (US) | 2025-09-10 | — | — | EP | claimed |
| EP-4590672-A1 | PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 | Merck Sharp & Dohme LLC (US) | 2025-07-30 | — | — | EP | claimed |
| CN-119907797-A | Phthalazine derivatives as NOD-like receptor protein 3 inhibitors | 默沙东有限责任公司 | 2025-04-29 | — | — | CN | claimed |
| WO-2024097598-A1 | TRIAZINES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 | MERCK SHARP & DOHME LLC (US) | 2024-05-10 | — | — | WO | claimed |
| US-20240124451-A1 | PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 | MERCK SHARP & DOHME LLC (US) | 2024-04-18 | — | — | US | claimed |
| WO-2024064245-A1 | PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 | MERCK SHARP & DOHME LLC (US) | 2024-03-28 | — | — | WO | claimed |
| EP-3430013-B1 | CARBAPENEM COMPOUNDS | ORCHID PHARMA LTD (IN) | 2023-11-15 | — | — | EP | claimed |
| CN-109415365-B | Carbapenem compounds | 幽兰医药有限公司 | 2022-08-09 | — | — | CN | claimed |
| US-20200291029-A1 | CARBAPENEM COMPOUNDS | MERCK SHARP & DOHME CORP. | 2020-09-17 | — | — | US | claimed |
| US-20190241574-A1 | PHENYL PHTHALAZINE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) | 2019-08-08 | — | — | US | claimed |
| WO-2016100157-A2 | 6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | claimed |
| EP-2838934-A2 | MOSITURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | Momentive Performance Materials Inc. (US) | 2015-02-25 | — | — | EP | claimed |
| US-20150038632-A1 | MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. | 2015-02-05 | — | — | US | claimed |
| WO-2013158236-A2 | MOSITURE CURABLE ORGANOPOLYSILOXANE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2013-10-24 | — | — | WO | claimed |
| US-7932389-B2 | treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis | MERCK SERONO S.A. (CH) | 2011-04-26 | — | — | US | claimed |
| EP-1768979-B1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCK SERONO SA (CH) | 2010-09-29 | — | — | EP | claimed |
| US-20080146806-A1 | Octahydropyrrolo[2,3C]Pyridine Derivatives and Pharmaceutical Use Thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2008-06-19 | — | — | US | claimed |
| EP-1768979-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-04 | — | — | EP | claimed |
| WO-2006008303-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-01-26 | — | — | WO | claimed |
| US-4711882-A | INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME; HYPOTENSIVE AND CARDIOTONIC AGENTS | PFIZER INC. (US) | 1987-12-08 | — | — | US | claimed |