Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.49 |
| ▸ | LSS | P48449 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATF4 | P18848 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744692 | 0.91 | KDM4E (0.51) | HTR1ADRD2HTR2AAVPR1BHRH3 | |
| SCHEMBL4743288 | 0.88 | HRH3 (0.56) | HRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4743111 | 0.88 | HRH3 (0.56) | HRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4743291 | 0.88 | HRH3 (0.48) | HTR1ADRD2HTR2AAVPR1BHRH3 | |
| SCHEMBL4743293 | 0.87 | MEN1 (0.56) | DRD2HRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4746694 | 0.85 | LSS (0.55) | HTR1ADRD2HTR2ALSSHRH3 | |
| SCHEMBL4745334 | 0.85 | HRH3 (0.47) | AVPR1BHRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4746716 | 0.82 | HRH3 (0.58) | HRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4744719 | 0.81 | HRH3 (0.53) | DRD2HRH3MEN1KMT2AKCNA5 | |
| SCHEMBL4745366 | 0.81 | HRH4 (0.53) | HTR1ADRD2HTR2AAVPR1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107321-A1 | HETEROCYCLIC COMPOUNDS USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107320-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008103866-A1 | SYNTHESIS OF INDOLES | MICROBIA, INC. (US) | 2008-08-28 | — | — | WO | disclosed |