Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745773 | 1.00 | TAAR1 (0.34) | TAAR1HRH3KCNA5SCN5ACYP2D6 | |
| SCHEMBL4745772 | 1.00 | TAAR1 (0.34) | TAAR1HRH3KCNA5SCN5ACYP2D6 | |
| SCHEMBL24834975 | 0.85 | NPC1 (0.34) | TAAR1HRH3CHRM2CHRM1 | |
| SCHEMBL600900 | 0.82 | CHRM1 (0.34) | TAAR1MAPK1OPRM1OPRL1CHRM2 | |
| SCHEMBL600899 | 0.82 | CHRM1 (0.34) | TAAR1MAPK1OPRM1OPRL1CHRM2 | |
| SCHEMBL14042280 | 0.80 | DPP4 (0.36) | HRH3CYP2D6MAPK1 | |
| SCHEMBL4748656 | 0.80 | DPP4 (0.36) | HRH3CYP2D6MAPK1 | |
| SCHEMBL4745995 | 0.79 | DPP4 (0.33) | TAAR1 | |
| SCHEMBL4745991 | 0.79 | DPP4 (0.33) | TAAR1 | |
| SCHEMBL4745992 | 0.79 | DPP4 (0.33) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119715-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |