Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042280 | 1.00 | DPP4 (0.36) | DPP4DPP7MAPK1NPC1RAB9A | |
| SCHEMBL26619643 | 0.82 | DPP4 (0.38) | DPP4DPP7HRH3ALDH1A1TSHR | |
| SCHEMBL4745773 | 0.80 | TAAR1 (0.34) | MAPK1HRH3CYP2D6 | |
| SCHEMBL4745772 | 0.80 | TAAR1 (0.34) | MAPK1HRH3CYP2D6 | |
| SCHEMBL4745776 | 0.80 | TAAR1 (0.34) | MAPK1HRH3CYP2D6 | |
| SCHEMBL14878281 | 0.79 | IKZF2 (0.37) | MAPK1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL4213726 | 0.78 | MAPK1 (0.43) | MAPK1KMT2AHRH3CYP2D6 | |
| SCHEMBL14041863 | 0.76 | DPP4 (0.38) | DPP4DPP7HRH3ALDH1A1TSHR | |
| SCHEMBL4745990 | 0.76 | DPP4 (0.38) | DPP4DPP7HRH3ALDH1A1TSHR | |
| SCHEMBL26619663 | 0.74 | DPP4 (0.35) | DPP4DPP7HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119715-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |