Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114418 | 0.83 | KDM4E (0.71) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL14068783 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL4746065 | 0.79 | RXFP1 (0.57) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL4745002 | 0.77 | ALDH1A1 (0.67) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL4746162 | 0.74 | KDM4E (0.70) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL22184914 | 0.73 | KDM4E (0.72) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL17603336 | 0.73 | IDH1 (1.00) | IDH1 | |
| SCHEMBL5695121 | 0.72 | ALDH1A1 (0.79) | KDM4EMAPTALDH1A1TDP1RECQL | |
| SCHEMBL27764047 | 0.70 | KDM4E (0.64) | KDM4EMAPTALDH1A1HPGDTDP1 | |
| SCHEMBL16938463 | 0.70 | KDM4E (0.53) | KDM4EMAPTALDH1A1HPGDAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | claimed |
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |