Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743608 | 0.86 | RXFP1 (0.53) | RXFP1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL4746968 | 0.83 | RXFP1 (0.63) | RXFP1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL4745410 | 0.83 | RXFP1 (0.69) | RXFP1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL4745088 | 0.81 | ALDH1A1 (0.57) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068786 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL4743044 | 0.80 | RXFP1 (0.56) | RXFP1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL4743064 | 0.79 | KDM4E (0.71) | RXFP1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL14068800 | 0.79 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL14068380 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10TSHRLMNA | |
| SCHEMBL4746075 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |