SCHEMBL4746103

SCHEMBL4746103

O=c1cc(-c2ccccc2)[nH]n1-c1ccccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOX4 Q9NPH5 2/20 1.00
NOX1 Q9Y5S8 2/20 1.00
KDM5A P29375 4/20 0.55
KDM4C Q9H3R0 4/20 0.55
KDM5B Q9UGL1 4/20 0.55
KDM4A O75164 2/20 0.55
KDM4E B2RXH2 4/20 0.54
SLC11A2 P49281 3/20 0.54
CHEK1 O14757 1/20 0.51
AURKA O14965 1/20 0.51
DAPK3 O43293 1/20 0.51
JAK2 O60674 1/20 0.51
PRKD3 O94806 1/20 0.51
MAP4K4 O95819 1/20 0.51
PAK4 O96013 1/20 0.51
ABL1 P00519 1/20 0.51
NTRK1 P04629 1/20 0.51
FYN P06241 1/20 0.51
CSF1R P07333 1/20 0.51
RET P07949 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4746365 0.78 NOX4 (0.63) NOX4NOX1KDM5AKDM4CKDM4E
SCHEMBL2085581 0.76 MAPT (0.69) NOX4NOX1KDM4EMEN1MAPT
SCHEMBL28358945 0.72 LDHA (0.58) NOX4NOX1KDM5BKDM4EGSK3B
SCHEMBL7601190 0.71 CHEK1 (0.58) NOX4NOX1KDM4CKDM4ESLC11A2
SCHEMBL23400261 0.70 NOX4 (0.54) NOX4NOX1KDM4EMEN1MAPT
SCHEMBL1414675 0.70 MAPT (0.65) NOX4NOX1KDM4EMEN1MAPT
SCHEMBL13167297 0.70 MAPT (0.62) NOX4NOX1KDM5AKDM4CKDM5B
SCHEMBL11755279 0.70 MAPT (0.65) NOX4NOX1KDM4EMEN1MAPT
SCHEMBL23400761 0.70 MAPT (0.57) NOX4NOX1KDM4EMEN1MAPT
SCHEMBL10551890 0.70 SLC11A2 (1.00) NOX4NOX1KDM5AKDM4CKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008121861-A2 PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2008-10-09 WO disclosed