Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22208127 | 0.79 | POLB (0.46) | EPHX2POLBHSD17B10SIGMAR1HRH3 | |
| SCHEMBL6123413 | 0.78 | POLB (0.38) | EPHX2POLBHSD17B10SIGMAR1HRH3 | |
| SCHEMBL1868922 | 0.78 | EPHX2 (0.49) | EPHX2POLBHSD17B10SIGMAR1HRH3 | |
| SCHEMBL4715595 | 0.77 | PDE7A (0.43) | EPHX2POLBHSD17B10SIGMAR1HRH3 | |
| SCHEMBL23573288 | 0.76 | POLB (0.56) | POLBHSD17B10SIGMAR1HRH3CHRM1 | |
| SCHEMBL3369574 | 0.76 | POLB (0.51) | POLBHSD17B10SIGMAR1HRH3CHRM1 | |
| SCHEMBL21847058 | 0.74 | ALDH1A1 (0.46) | POLBHSD17B10SIGMAR1 | |
| SCHEMBL4749850 | 0.73 | CHRM1 (0.37) | EPHX2POLBHSD17B10SIGMAR1HRH3 | |
| SCHEMBL14041715 | 0.73 | — | — | |
| SCHEMBL3020717 | 0.72 | CHRM1 (0.40) | POLBSIGMAR1HRH3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119716-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |