Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746364 | 1.00 | REN (0.44) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL2849337 | 0.93 | REN (0.46) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL2849335 | 0.93 | REN (0.46) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL5610964 | 0.91 | REN (0.46) | RENGRM5NPC1RAB9ACTSA | |
| SCHEMBL5610962 | 0.91 | REN (0.46) | RENGRM5NPC1RAB9ACTSA | |
| SCHEMBL2850288 | 0.90 | REN (0.49) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL5592225 | 0.90 | REN (0.42) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL3568209 | 0.90 | REN (0.42) | RENMAPTSMN1; SMN2 | |
| SCHEMBL5592227 | 0.90 | REN (0.42) | RENGRM5NPC1RAB9ATP53 | |
| SCHEMBL3568210 | 0.90 | REN (0.42) | RENMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |