Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592225 | 1.00 | REN (0.42) | RENGRM5TP53NPC1RAB9A | |
| SCHEMBL3570951 | 0.90 | REN (0.40) | REN | |
| SCHEMBL3570954 | 0.90 | REN (0.40) | REN | |
| SCHEMBL3570948 | 0.90 | REN (0.40) | REN | |
| SCHEMBL4746368 | 0.90 | REN (0.44) | RENGRM5TP53NPC1RAB9A | |
| SCHEMBL2849337 | 0.90 | REN (0.46) | RENGRM5TP53NPC1RAB9A | |
| SCHEMBL2849335 | 0.90 | REN (0.46) | RENGRM5TP53NPC1RAB9A | |
| SCHEMBL4746364 | 0.90 | REN (0.44) | RENGRM5TP53NPC1RAB9A | |
| SCHEMBL5610962 | 0.87 | REN (0.46) | RENGRM5NPC1RAB9A | |
| SCHEMBL5610964 | 0.87 | REN (0.46) | RENGRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117482-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | claimed |
| WO-2007117482-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |