Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 3/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474794 | 0.90 | HSD11B1 (0.36) | ROCK2HSD11B1FFAR4KCNJ6KCNJ5 | |
| SCHEMBL474903 | 0.88 | CMA1 (0.35) | HSD11B1CHRM3 | |
| SCHEMBL13897773 | 0.85 | HSD11B1 (0.35) | ROCK2HSD11B1MCHR1KCNJ6KCNJ5 | |
| SCHEMBL474719 | 0.85 | HSD11B1 (0.39) | ROCK2HSD11B1MCHR1KCNJ6KCNJ5 | |
| SCHEMBL474674 | 0.85 | HSD11B1 (0.39) | ROCK2P2RX7HSD11B1MCHR1PARP1 | |
| SCHEMBL474718 | 0.85 | HSD11B1 (0.39) | ROCK2HSD11B1MCHR1KCNJ6KCNJ5 | |
| SCHEMBL474673 | 0.85 | HSD11B1 (0.39) | ROCK2P2RX7HSD11B1MCHR1PARP1 | |
| SCHEMBL474792 | 0.84 | HSD11B1 (0.38) | ROCK2P2RX7HSD11B1PARP1 | |
| SCHEMBL474851 | 0.83 | AKR1C2 (0.38) | ROCK2HSD11B1MCHR1FFAR4 | |
| SCHEMBL474642 | 0.83 | AKR1C2 (0.38) | ROCK2HSD11B1MCHR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | claimed |