Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.30 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.30 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474638 | 0.90 | ROCK2 (0.33) | HSD11B1PARP1ROCK2FFAR4KCNJ6 | |
| SCHEMBL474792 | 0.89 | HSD11B1 (0.38) | HSD11B1PARP1ROCK2CYP2D6CYP2B6 | |
| SCHEMBL3878885 | 0.88 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL474673 | 0.87 | HSD11B1 (0.39) | HSD11B1PARP1ROCK2CYP2D6CYP2B6 | |
| SCHEMBL474718 | 0.87 | HSD11B1 (0.39) | HSD11B1PARP1ROCK2KCNJ6KCNJ5 | |
| SCHEMBL474719 | 0.87 | HSD11B1 (0.39) | HSD11B1PARP1ROCK2KCNJ6KCNJ5 | |
| SCHEMBL474674 | 0.87 | HSD11B1 (0.39) | HSD11B1PARP1ROCK2CYP2D6CYP2B6 | |
| SCHEMBL474851 | 0.86 | AKR1C2 (0.38) | HSD11B1ROCK2FFAR4SCN9A | |
| SCHEMBL13897773 | 0.86 | HSD11B1 (0.35) | HSD11B1PARP1ROCK2CYP2D6CYP2B6 | |
| SCHEMBL474642 | 0.86 | AKR1C2 (0.38) | HSD11B1ROCK2FFAR4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | claimed |