Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789166 | 0.80 | KCNH2 (0.51) | KCNH2SCN9ASCN5ABTKSLC6A5 | |
| SCHEMBL4788640 | 0.77 | KCNH2 (0.56) | KCNH2SCN9ASCN5ASLC6A5MTNR1A | |
| SCHEMBL7031626 | 0.77 | KCNH2 (0.56) | KCNH2SCN9ASCN5ASLC6A5MTNR1A | |
| SCHEMBL7031622 | 0.77 | KCNH2 (0.56) | KCNH2SCN9ASCN5ASLC6A5MTNR1A | |
| SCHEMBL6824793 | 0.77 | KCNH2 (0.47) | KCNH2SCN9ASCN5ASLC6A5HTR2A | |
| SCHEMBL6819857 | 0.77 | KCNH2 (0.47) | KCNH2SCN9ASCN5ASLC6A5HTR2A | |
| SCHEMBL4842065 | 0.76 | SCN9A (1.00) | KCNH2SCN9ASCN5ATRPV1DRD4 | |
| SCHEMBL4842078 | 0.76 | SCN9A (1.00) | KCNH2SCN9ASCN5ATRPV1DRD4 | |
| SCHEMBL7026264 | 0.74 | MTNR1A (0.59) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL6820334 | 0.74 | KCNH2 (0.55) | KCNH2SCN9ASCN5ASLC6A5MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |