Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788189 | 0.89 | KCNH2 (0.40) | KCNH2SCN5ASCN9AEPHX2SLC6A5 | |
| SCHEMBL4746920 | 0.80 | KCNH2 (0.61) | KCNH2SCN5ASCN9AEPHX2PRKAA2 | |
| SCHEMBL4749982 | 0.78 | SCN9A (0.77) | KCNH2SCN5ASCN9AEPHX2DRD4 | |
| SCHEMBL4788153 | 0.76 | NOD1 (0.56) | KCNH2SCN5ASCN9ADRD4HTR2A | |
| SCHEMBL4862508 | 0.74 | SCN9A (0.42) | KCNH2SCN5ASCN9AEPHX2MCHR1 | |
| SCHEMBL4862497 | 0.74 | SCN9A (0.42) | KCNH2SCN5ASCN9AEPHX2MCHR1 | |
| SCHEMBL4786516 | 0.74 | MCHR1 (0.44) | KCNH2SCN5ASCN9AEPHX2MCHR1 | |
| SCHEMBL4788141 | 0.73 | BRAF (0.41) | KCNH2SCN5ASCN9ASLC6A5DRD4 | |
| SCHEMBL13841325 | 0.71 | EPHX2 (0.81) | EPHX2HRH3HSD11B1 | |
| SCHEMBL4787977 | 0.71 | L3MBTL1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |