Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.58 |
| ▸ | BCL2 | P10415 | 4/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | RPA1 | P27694 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PPP1CA | P62136 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565035 | 0.84 | RPA1 (0.66) | RPA1SMN1; SMN2PPP1CAL3MBTL1CYP1A2 | |
| SCHEMBL28180312 | 0.82 | MDM2 (0.81) | MDM2MCL1BCL2RPA1SMN1; SMN2 | |
| SCHEMBL570061 | 0.82 | RPA1 (0.63) | MDM2MCL1BCL2RPA1SMN1; SMN2 | |
| SCHEMBL2565079 | 0.82 | PPP1CA (0.64) | RPA1SMN1; SMN2PPP1CA | |
| SCHEMBL4689569 | 0.81 | RPA1 (0.48) | MCL1RPA1SMN1; SMN2PPP1CAL3MBTL1 | |
| SCHEMBL1413877 | 0.81 | KMT2A (0.58) | RPA1SMN1; SMN2PPP1CAL3MBTL1MME | |
| SCHEMBL4695131 | 0.81 | MME (0.55) | MDM2MCL1BCL2PPARGPPARD | |
| SCHEMBL4694701 | 0.81 | FAAH (0.56) | MDM2MCL1BCL2PPARGPPARD | |
| SCHEMBL20656279 | 0.80 | RPA1 (0.47) | PPARGPPARARPA1SMN1; SMN2PPP1CA | |
| SCHEMBL4688189 | 0.79 | NR1H4 (0.61) | PPARGPPARARPA1SMN1; SMN2PPP1CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685113-B1 | SUBSTITUTED PYRAZOLES AS PPAR AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | PPARD, PPARA, PPARG | MDM2 2189/4885MCL1 3380/4885BCL2 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.