Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.46 |
| ▸ | RPA1 | P27694 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656186 | 0.87 | CHRNB2 (0.60) | NR1H4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL570061 | 0.82 | RPA1 (0.63) | RPA1SMN1; SMN2ALDH1A1PPP1CAMARS1 | |
| SCHEMBL2565035 | 0.81 | RPA1 (0.66) | RPA1SMN1; SMN2PPP1CAMARS1L3MBTL1 | |
| SCHEMBL4689569 | 0.81 | RPA1 (0.48) | RPA1SMN1; SMN2ALDH1A1PPP1CAL3MBTL1 | |
| SCHEMBL1413877 | 0.81 | KMT2A (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4RPA1 | |
| SCHEMBL4692489 | 0.81 | MARS1 (0.60) | NR1H4PPARGPPARARPA1SMN1; SMN2 | |
| SCHEMBL4693346 | 0.81 | FAAH (0.56) | NR1H4PPARGPPARACHRNB2CHRNB4 | |
| SCHEMBL20656279 | 0.80 | RPA1 (0.47) | PPARGPPARARPA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4690961 | 0.79 | PPARG (0.60) | NR1H4PPARGPPARAMARS1 | |
| SCHEMBL4746928 | 0.79 | MDM2 (0.58) | PPARGPPARARPA1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685113-B1 | SUBSTITUTED PYRAZOLES AS PPAR AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1685113-B1 | SUBSTITUTED PYRAZOLES AS PPAR AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021030-A1 | Substituted Pyrazoles As Ppar Agonists | PPARD, PPARA, PPARG | NR1H4 73/4885PPARG 3/4885PPARA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.