Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606162 | 0.94 | ALDH1A1 (0.51) | LMNANPSR1BRD4EPHX2ALDH1A1 | |
| SCHEMBL14247649 | 0.89 | USP30 (0.52) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL15342506 | 0.89 | USP30 (0.52) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL15342513 | 0.89 | USP30 (0.52) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL14041860 | 0.88 | LMNA (0.46) | LMNANPSR1EPHX2ALDH1A1MAPT | |
| SCHEMBL29847375 | 0.87 | ALDH1A1 (0.46) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL29848622 | 0.87 | ALDH1A1 (0.46) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL28563880 | 0.86 | BRD4 (0.49) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL18928570 | 0.86 | BRD4 (0.49) | LMNABRD4ALDH1A1MAPTMAPK1 | |
| SCHEMBL16896124 | 0.86 | USP30 (0.49) | LMNANPSR1BRD4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |