Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.55 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746478 | 0.90 | PDPK1 (0.52) | PDPK1TP53MAPTPOLBBLM | |
| SCHEMBL4747760 | 0.87 | PDPK1 (0.56) | PDPK1 | |
| SCHEMBL4747112 | 0.79 | PDPK1 (0.53) | PDPK1 | |
| SCHEMBL4747812 | 0.77 | PDPK1 (0.56) | PDPK1 | |
| SCHEMBL4747754 | 0.77 | PDPK1 (0.68) | PDPK1POLBKMT2AFLT1 | |
| SCHEMBL4929414 | 0.75 | PDPK1 (0.58) | PDPK1FGFR1FLT1FBP1 | |
| SCHEMBL4743599 | 0.75 | PDPK1 (0.56) | PDPK1 | |
| SCHEMBL4747109 | 0.74 | PDPK1 (0.70) | PDPK1MAPTPOLB | |
| SCHEMBL4745738 | 0.73 | PDPK1 (0.61) | PDPK1 | |
| SCHEMBL4785867 | 0.72 | PDPK1 (0.53) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109599-A1 | PYRIMIDO [5,4-C] QUINOLINE-2, 4-DIAMINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |