Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747115 | 0.87 | PDPK1 (0.55) | PDPK1 | |
| SCHEMBL4746478 | 0.80 | PDPK1 (0.52) | PDPK1EGFR | |
| SCHEMBL4747112 | 0.78 | PDPK1 (0.53) | PDPK1PDGFRBPDGFRA | |
| SCHEMBL4747812 | 0.77 | PDPK1 (0.56) | PDPK1 | |
| SCHEMBL4747754 | 0.77 | PDPK1 (0.68) | PDPK1LMNATLR7 | |
| SCHEMBL4929414 | 0.74 | PDPK1 (0.58) | PDPK1EGFR | |
| SCHEMBL4743599 | 0.74 | PDPK1 (0.56) | PDPK1 | |
| SCHEMBL4747109 | 0.73 | PDPK1 (0.70) | PDPK1KDM4EHPGDTLR7 | |
| SCHEMBL4745738 | 0.73 | PDPK1 (0.61) | PDPK1TLR7 | |
| SCHEMBL4747140 | 0.72 | PDPK1 (0.43) | PDPK1PDGFRBPDGFRAKDM4ETLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109599-A1 | PYRIMIDO [5,4-C] QUINOLINE-2, 4-DIAMINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2008-09-12 | — | — | WO | claimed |