SCHEMBL4747249

SCHEMBL4747249

CCc1cc2cc[nH]c(=O)c2c(N2CCCCC2)n1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.43
ZAP70 P43403 4/20 0.37
JAK3 P52333 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 1/20 0.35
TMIGD3 P0DMS9 1/20 0.35
RAB9A P51151 1/20 0.35
NPY5R Q15761 1/20 0.35
SCN10A Q9Y5Y9 2/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
XBP1 P17861 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
CHEK1 O14757 2/20 0.34
MAT2A P31153 1/20 0.34
DAO P14920 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4750208 0.80 JAK2 (0.43) JAK2ZAP70JAK3KDM4ENPY5R
SCHEMBL5814327 0.80 JAK2 (0.43) JAK2ZAP70JAK3SCN10AMAPK1
SCHEMBL4747891 0.77 SYK (0.39) SMN1; SMN2KDM4ENPY5RALDH1A1GAA
SCHEMBL4747717 0.76 GRM2 (0.36) SMN1; SMN2KDM4ENPY5RALDH1A1GAA
SCHEMBL15760939 0.71 ZAP70 (0.40) JAK2ZAP70CHEK1
SCHEMBL1158384 0.71 HDAC6 (0.41) JAK2ZAP70JAK3
SCHEMBL6526413 0.70 MAP3K12 (0.47) JAK2ZAP70
SCHEMBL1159802 0.69 EGFR (0.39) JAK2ZAP70
SCHEMBL17687624 0.62 ALDH1A1 (0.49) SMN1; SMN2KDM4ERAB9AALDH1A1GAA
SCHEMBL15760925 0.62 JAK2 (0.38) JAK2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO claimed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO claimed
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO disclosed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO disclosed