Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747891 | 0.86 | SYK (0.39) | GRM2ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL5819969 | 0.83 | DRD2 (0.37) | GRM2ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL5816427 | 0.83 | GRM2 (0.35) | GRM2ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL4747249 | 0.76 | JAK2 (0.43) | ALDH1A1KDM4ESMN1; SMN2MAPTHTT | |
| SCHEMBL4750623 | 0.73 | GRM2 (0.40) | GRM2ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL5814919 | 0.71 | KDM5A (0.33) | GRM2ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL4788702 | 0.69 | GRM2 (0.36) | GRM2KDM4EMAPTTSHRGAA | |
| SCHEMBL4747299 | 0.66 | GRM2 (0.38) | GRM2ALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL5820088 | 0.66 | SYK (0.39) | ALDH1A1KDM4EMAPTHTTTSHR | |
| SCHEMBL5813982 | 0.66 | SYK (0.39) | GRM2ALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2006112666-A1 | PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SK CHEMICALS CO., LTD. (KR) | 2006-10-26 | — | — | WO | claimed |
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | disclosed |
| WO-2006112666-A1 | PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SK CHEMICALS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |