Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.62 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747620 | 0.90 | SCN9A (0.64) | SCN9AKCNH2SCN5APOLBMAPT | |
| SCHEMBL840782 | 0.77 | SCN9A (1.00) | SCN9AKCNH2SCN5APOLBMAPT | |
| SCHEMBL20288009 | 0.77 | SCN9A (1.00) | SCN9AKCNH2SCN5APOLBMAPT | |
| SCHEMBL4787985 | 0.71 | MTNR1A (0.48) | SCN9AKCNH2SCN5AMAPT | |
| SCHEMBL4788578 | 0.70 | SCN9A (0.47) | SCN9AKCNH2SCN5A | |
| SCHEMBL4786772 | 0.67 | MTNR1A (0.49) | SCN9AKCNH2SCN5AMAPT | |
| SCHEMBL4788464 | 0.66 | SCN9A (0.71) | SCN9AKCNH2SCN5A | |
| SCHEMBL316094 | 0.66 | KCNH2 (0.49) | SCN9AKCNH2SCN5APOLBMAPT | |
| SCHEMBL4788828 | 0.66 | SCN9A (0.70) | SCN9AKCNH2SCN5A | |
| SCHEMBL4788313 | 0.66 | KCNH2 (0.55) | SCN9AKCNH2SCN5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |