Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786931 | 0.86 | KCNH2 (0.58) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4785773 | 0.84 | KCNH2 (0.72) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788501 | 0.84 | KCNH2 (0.72) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4789252 | 0.84 | KCNH2 (0.50) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4786772 | 0.82 | MTNR1A (0.49) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4787985 | 0.82 | MTNR1A (0.48) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL841303 | 0.78 | SCN9A (0.71) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL840155 | 0.78 | SCN9A (0.57) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4786804 | 0.73 | MTNR1A (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788553 | 0.72 | KCNH2 (0.55) | KCNH2SCN9AMTNR1AMTNR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |