Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.69 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747089 | 0.96 | SCN9A (0.73) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4842065 | 0.82 | SCN9A (1.00) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4842078 | 0.82 | SCN9A (1.00) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4749736 | 0.82 | SCN9A (0.73) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4788572 | 0.81 | MTNR1A (0.51) | SCN9ASCN5AKCNH2HTR2ADRD4 | |
| SCHEMBL4746908 | 0.81 | KCNH2 (0.49) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4749982 | 0.80 | SCN9A (0.77) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4750039 | 0.76 | SCN9A (0.66) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4750460 | 0.76 | SCN9A (0.65) | SCN9ASCN5AKCNH2HTR2ADRD3 | |
| SCHEMBL4750025 | 0.75 | SCN9A (0.65) | SCN9ASCN5AKCNH2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |