Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 7/20 | 0.52 |
| ▸ | ITK | Q08881 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746451 | 0.78 | BTK (0.56) | PLCG1BTKITK | |
| SCHEMBL16176821 | 0.75 | BTK (0.76) | JAK3PLCG1BTKITK | |
| SCHEMBL14069150 | 0.73 | BTK (0.50) | PLCG1BTKITK | |
| SCHEMBL1463453 | 0.72 | JAK3 (1.00) | JAK3MAP4K4ALDH1A1HTTMEN1 | |
| SCHEMBL15587657 | 0.72 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL4746500 | 0.71 | TNIK (0.58) | SMN1; SMN2 | |
| SCHEMBL12746101 | 0.71 | SMN1; SMN2 (0.64) | JAK3MAP4K4ALDH1A1HTTMEN1 | |
| SCHEMBL17938939 | 0.70 | PLCG1 (1.00) | PLCG1BTKITK | |
| SCHEMBL17938942 | 0.70 | PLCG1 (1.00) | PLCG1BTKITK | |
| SCHEMBL16176566 | 0.70 | BTK (0.77) | PLCG1BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |