Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.56 |
| ▸ | ITK | Q08881 | 11/20 | 0.56 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743377 | 0.89 | PRMT5 (0.46) | BTKITKRIPK1IGF1RCDK8 | |
| SCHEMBL14069150 | 0.87 | BTK (0.50) | BTKITKPLCG1NTRK1CDK8 | |
| SCHEMBL4747788 | 0.78 | JAK3 (0.56) | BTKITKPLCG1 | |
| SCHEMBL14069152 | 0.76 | PRMT5 (0.42) | BTKITKCDK8 | |
| SCHEMBL16176821 | 0.75 | BTK (0.76) | BTKITKPLCG1RIPK1IGF1R | |
| SCHEMBL4746500 | 0.74 | TNIK (0.58) | NTRK1 | |
| SCHEMBL21118214 | 0.72 | BTK (0.82) | BTKITKPLCG1RIPK1IGF1R | |
| SCHEMBL16176744 | 0.72 | BTK (1.00) | BTKITKPLCG1RIPK1IGF1R | |
| SCHEMBL4747692 | 0.71 | TNIK (0.63) | ITKRIPK1NTRK1 | |
| SCHEMBL4166436 | 0.71 | AXL (0.55) | BTKITKPLCG1RIPK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |