Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747832 | 1.00 | CYP1A2 (0.43) | CYP1A2POLBCYP2C19NPSR1RAB9A | |
| SCHEMBL4695113 | 0.90 | CYP1A2 (0.56) | CYP1A2POLBCYP2C19NPSR1RAB9A | |
| SCHEMBL4744975 | 0.90 | ALDH1A1 (0.51) | CYP1A2POLBCYP2C19NPSR1RAB9A | |
| SCHEMBL4745685 | 0.88 | MAPT (0.48) | RAB9ASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL4745679 | 0.88 | MAPT (0.48) | RAB9ASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL5896791 | 0.87 | MAPT (0.50) | POLBRAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL29385179 | 0.87 | MAPT (0.50) | POLBRAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4688665 | 0.87 | MAPT (0.50) | POLBRAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5896804 | 0.87 | MAPT (0.50) | POLBRAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4689049 | 0.85 | RAB9A (0.42) | POLBRAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |