Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.58 |
| ▸ | MPL | P40238 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | WNT3A | P56704 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480743 | 0.92 | KMT2A (0.60) | KMT2AMEN1TRPA1TRPV4MPL | |
| SCHEMBL480671 | 0.83 | TRPA1 (0.58) | KMT2AMEN1TRPA1TRPV4MPL | |
| SCHEMBL17400523 | 0.80 | ABL1 (0.70) | KMT2AMEN1TRPA1TRPV4MPL | |
| SCHEMBL474715 | 0.78 | ROCK2 (0.62) | KMT2AMEN1TRPA1MPLPRKACA | |
| SCHEMBL480598 | 0.75 | TRPA1 (0.61) | KMT2AMEN1TRPA1TRPV4MPL | |
| SCHEMBL16366780 | 0.74 | TRPA1 (0.65) | TRPA1TRPV4 | |
| SCHEMBL13175082 | 0.74 | TRPA1 (0.78) | TRPA1TRPV4 | |
| SCHEMBL474905 | 0.74 | TRPA1 (0.78) | TRPA1TRPV4 | |
| SCHEMBL480562 | 0.74 | TRPA1 (0.59) | KMT2AMEN1TRPA1TRPV4 | |
| SCHEMBL13076688 | 0.74 | TRPA1 (0.74) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411396-A2 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2012-02-01 | — | — | EP | disclosed |