Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748218 | 1.00 | MAPT (0.53) | MAPTPOLBGAALMNAMAPK1 | |
| SCHEMBL1974848 | 0.94 | MAPT (0.51) | MAPTGAALMNAMAPK1HSD17B10 | |
| SCHEMBL1717228 | 0.94 | MAPT (0.51) | MAPTGAALMNAMAPK1HSD17B10 | |
| SCHEMBL1717226 | 0.94 | MAPT (0.51) | MAPTGAALMNAMAPK1HSD17B10 | |
| SCHEMBL11760780 | 0.89 | MAPT (0.53) | MAPTPOLBGAALMNAMAPK1 | |
| SCHEMBL11715338 | 0.86 | ALDH1A1 (0.68) | MAPTPOLBLMNAMAPK1HPGD | |
| SCHEMBL11715321 | 0.86 | ALDH1A1 (0.68) | MAPTPOLBLMNAMAPK1HPGD | |
| SCHEMBL10862595 | 0.85 | MAPT (0.58) | MAPTLMNAMAPK1HPGDALDH1A1 | |
| SCHEMBL4768319 | 0.85 | MAPT (0.60) | MAPTPOLBGAALMNAMAPK1 | |
| SCHEMBL4768324 | 0.85 | MAPT (0.60) | MAPTPOLBGAALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117079-A1 | ANTIMICROBIAL COMPOUNDS BASED UPON 4-AMINOQUINOLINE | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |