Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768324 | 1.00 | MAPT (0.60) | MAPTTDP1DHODHPOLBALDH1A1 | |
| SCHEMBL11760780 | 0.95 | MAPT (0.53) | MAPTTDP1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10862592 | 0.90 | MAPT (0.58) | MAPTTDP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10862595 | 0.90 | MAPT (0.58) | MAPTTDP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10860691 | 0.89 | RAB9A (0.54) | MAPTPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10860698 | 0.89 | RAB9A (0.54) | MAPTPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11721179 | 0.88 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL11721171 | 0.88 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL6825169 | 0.88 | ALDH1A1 (0.59) | MAPTTDP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6825162 | 0.88 | ALDH1A1 (0.59) | MAPTTDP1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613322-A4 | AMINOQUINOLINE COMPOUNDS | TAIGEN BIOTECHNOLOGY CO LTD (TW) | 2008-08-13 | — | — | EP | disclosed |
| US-7183413-B2 | Aminoquinoline compounds | TAIGEN BIOTECHNOLOGY (TW) | 2007-02-27 | — | — | US | disclosed |
| EP-1613322-A2 | AMINOQUINOLINE COMPOUNDS | Taigen Biotechnology (TW) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091485-A2 | AMINOQUINOLINE COMPOUNDS | TAIGEN BIOTECHNOLOGY (TW) | 2004-10-28 | — | — | WO | disclosed |
| US-20040209902-A1 | e.g., 1,4-bis[2,6-dimethylquinolin-4ylamino]butane; used to treat inflammatory and immune diseases by binding to CXCR3 receptors. | TAIGEN BIOTECHNOLOGY (TW) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209902-A1 | e.g., 1,4-bis[2,6-dimethylquinolin-4ylamino]butane; used to treat inflammatory and immune diseases by binding to CXCR3 receptors. | CXCR3, CXCL10, CXCR1 | MAPT 4134/4885TDP1 3240/4885DHODH 1563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.