⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745759 | 0.94 | — | — | |
| SCHEMBL2796087 | 0.87 | — | — | |
| SCHEMBL373953 | 0.82 | — | — | |
| SCHEMBL19449959 | 0.80 | OPRM1 (0.38) | — | |
| SCHEMBL17621189 | 0.78 | — | — | |
| SCHEMBL15233550 | 0.77 | — | — | |
| SCHEMBL12000009 | 0.77 | KMT2A (0.39) | — | |
| SCHEMBL21315293 | 0.76 | KMT2A (0.30) | — | |
| SCHEMBL31601155 | 0.75 | CYP4F2 (0.34) | — | |
| SCHEMBL10367674 | 0.74 | KDM4E (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185563-B1 | OXASPIROCYCLIC SPIRO-SUBSTITUTED TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |
| US-8859466-B2 | Oxaspirocyclic spiro-substituted tetramic acid and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859466-B2 | Oxaspirocyclic spiro-substituted tetramic acid and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263424-A1 | Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | US | disclosed |
| WO-2009015801-A1 | OXASPIROCYCLIC SPIRO-SUBSTITUTED TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008119716-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119716-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |