Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23523189 | 0.86 | NR1H2 (0.36) | DPP4DPP8DPP9NR1H2 | |
| SCHEMBL342785 | 0.81 | NR1H2 (0.43) | HSD11B1NR1H2 | |
| SCHEMBL342787 | 0.81 | NR1H2 (0.43) | HSD11B1NR1H2 | |
| SCHEMBL342786 | 0.81 | NR1H2 (0.43) | HSD11B1NR1H2 | |
| SCHEMBL343016 | 0.80 | NR1H2 (0.58) | CTSKDPP4CTSSNR1H2 | |
| SCHEMBL343014 | 0.80 | NR1H2 (0.58) | CTSKDPP4CTSSNR1H2 | |
| SCHEMBL343015 | 0.80 | NR1H2 (0.58) | CTSKDPP4CTSSNR1H2 | |
| SCHEMBL14697421 | 0.79 | — | — | |
| SCHEMBL28077869 | 0.76 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL2461573 | 0.73 | ALDH1A1 (0.37) | HSD11B1CTSBCTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411011-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD K.K. (JP) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111056-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-09-30 | — | — | WO | disclosed |