Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745998 | 0.89 | LTB4R (0.38) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4226154 | 0.86 | CYSLTR2 (0.38) | LTB4RCYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4050972 | 0.84 | LTB4R (0.45) | LTB4RPDE10ACYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4230528 | 0.83 | CYSLTR2 (0.37) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4242583 | 0.78 | LTB4R (0.38) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4060665 | 0.77 | LTB4R (0.38) | LTB4RPDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL13765226 | 0.76 | LTB4R (0.35) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4228194 | 0.76 | CYSLTR2 (0.39) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 | |
| SCHEMBL4052805 | 0.76 | LTB4R (0.46) | LTB4RPDE10ACYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4230775 | 0.76 | TBXAS1 (0.39) | LTB4RPDE10ACYSLTR2CYSLTR1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | claimed |